Suppl 1 Centennial Influenza Pandemic

From H5N1 to HxNy: An epidemiologic overview of human infections with avian influenza in the Western Pacific Region, 2003–2017

Sarah Hamid, Yuzo Arima, Erica Dueger, Frank Konings, Leila Bell, Chin-Kei Lee, Dapeng Luo, Satoko Otsu, Babatunde Olowokure, Ailan Li, WPRO Health Emergencies Programme Team


Since the first confirmed human infection with avian influenza A(H5N1) virus was reported in Hong Kong Special Administrative Region in 1997, sporadic zoonotic avian influenza viruses causing illness in humans have been identified globally, with the WHO Western Pacific Region as one of the hotspots. From November 2003, when a resurgence of H5N1 virus activity in humans and animals occurred, through September 2017, 1,838 human infections with avian influenza viruses in the region were reported to WHO. Viruses infecting humans were A(H5N1), A(H5N6), A(H6N1), A(H7N9), A(H9N2) and A(H10N8). The vast majority of infections were with H7N9 (n=1,562) and H5N1 (n=238) viruses, and most (n=1583, 86%) were reported from December through April. In poultry and wild birds, H5N1 and H5N6 subtypes were the most widely distributed, with outbreaks reported from ten and eight countries and areas, respectively.

Regional analyses of human infections with avian influenza subtypes revealed distinct patterns and variations in epidemiology across countries, age, and time. Such epidemiologic patterns may not be apparent from aggregated global summaries or isolated country reports; regional assessment can offer additional insight that can inform risk assessment and response efforts. As infected animals and contaminated environments are the primary source of human infections, regional analyses that bring together surveillance data from human and animal health sectors are an important basis for exposure and transmission risk assessment and public health action. A One Health approach combining sustained event-based surveillance with enhanced collaboration between the human, animal (domestic and wildlife), and environmental sectors will provide a basis to inform joint risk assessment and coordinated response capacities

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